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KMID : 1103920100160020187
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Korean Journal of Hepatology
2010 Volume.16 No. 2 p.187 ~ p.191
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Occurrence of diabetic ketoacidosis and autoimmune thyroiditis in a patient treated with pegylated interferon-alpha 2b and ribavirin for chronic hepatitis C
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Lee Yun-Nah
Jung Seung-Won
Lim Jae-Hee
Ryu Yang-Seon
Jeon Seong-Ran
Kim Sang-Gyune
Jang Jae-Young
Kim Young-Seok
Kim Boo-Sung
Roh Mi-Oh
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Abstract
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Combined pegylated interferon and ribavirin therapy for chronic hepatitis C infection cause a wide range of side effects, including flu-like syndrome, hematological abnormalities, cardiovascular symptoms, gastrointestinal symptoms, pulmonary dysfunction, depression, and retinopathy. Interferon-alpha has been shown to be related to the development of various autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroid disease, and type 1 diabetes mellitus (DM). Type 1 DM and thyroid disease respectively develop in 0.08～2.61% and 10～15% of patients treated with combined interferon-alpha and ribavirin for chronic hepatitis C. The coexistence of type 1 DM and autoimmune thyroiditis was rarely reported. We report a case of a 33-year-old female patient with chronic hepatitis C who simultaneously developed diabetic ketoacidosis and autoimmune thyroiditis after treatment with pegylated interferon-alpha 2b and ribavirin.
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KEYWORD
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Hepatitis C, chronic, Interferon Alfa-2b, Diabetes Mellitus, type 1, Thyroiditis, autoimmune
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